Duovir N Tablet (Lamivudine/Zidovudine/Nevirapine)

Duovir N Tablet contains the active ingredient Lamivudine + Nevirapine + Zidovudine. It is a combination of three antiretroviral medicines. Lamivudine and Zidovudine mainly belong to the class of medications called nucleoside/nucleotide reverse transcriptase inhibitors. Nevirapine belongs to the class of medication called non-nucleoside reverse transcriptase inhibitors. It is used to treat HIV-1 infection.

This tablet is not advised for patients with anemia (low red blood cells) or neutropenia (low white blood cells). Inform your doctor if you have any liver disease, including hepatitis B or C, kidney disease, or are overweight. The administration of this tablet is associated with hematologic toxicity (decrease in blood cells), muscle weakness, liver diseases and infection, and lactic acidosis (acid buildup due to problems in the body's metabolism). This medication is not advised for children less than 35 kg. Lamivudine, Nevirapine, and zidovudine tablets may cause decreased fertility in females. Talk to your physician if you have any concerns about fertility

Treatment of HIV -1 infection

Duovir N Tablet is a combination of three antiretroviral medicines. Lamivudine and Zidovudine work by inhibiting the reverse transcriptase enzyme of HIV, restricting viral genome replication, and reducing the production of new infectious viral particles. It mainly interferes with reverse transcription and inhibits the spread of HIV. Nevirapine directly binds to reverse transcriptase (RT) and blocks RNA-dependent and DNA-dependent polymerase activities by disrupting the enzyme.

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, supplements, and herbal products. Certain medications, including ganciclovir, interferon alfa, and ribavirin, may exacerbate the toxicity of zidovudine interaction with Duovir N Tablet and reduce its effectiveness by causing undesirable side effects

• Store Duovir N Tablet below 30°C
• Keep the medicine out of reach of children and pets

Take the Duovir N Tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.